Mechanical Properties of Axons

Mechanical Properties of Axons

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To understand the mechanical properties of the axon,we introduced a coarse-grain molecular dynamics model for the axon membrane skeleton of non-myelinated neurons.We found that the axon plasma membrane has two distinct Young's moduli that are correlated with its geometric structure,which is characterized by stiff actin rings connected by extended spectrin filaments oriented along the axon.Author:Yihao Zhang,Krithika Abiraman,He Li,David M.Pierce,Anastasios V.Tzingounis,George LykotrafitiCited by:33Publish Year:2017Modeling of the axon membrane skeleton structure and

Was this helpful?(PDF) Mechanical Properties of Axons - ResearchGateMechanical Properties of Axons.A 'read' is counted each time someone views a publication summary (such as the title,abstract,and list of authors),clicks on a figure,or views or downloads theThe mechanical importance of myelination in the central Apr 08,2017 Mechanical Properties of Axons#0183;cross-link up to 40 axons per oligodendrocyte (Baumann and Pham-Dinh,2001).This results in a dense network of cross-linked cells as illustrated in Fig.1.While it seems intuitive that this tightly cross-linked network aects the mechanical properties of the tissue,surpris-ingly,the neuron-oligodendrocyte network has not been acknowledgedThe Mechanical Properties of Plastics 2019-12-09 Dec 09,2019 Mechanical Properties of Axons#0183;The Mechanical Properties of Plastics Mechanical properties describe the materials reaction to an applied force,such as tension,compression,and impact.The most common type of specimen for testing plastics in tension is commonly referred to as a dogbone because of its tabbed ends and reduced cross sectional area.

Some results are removed in response to a notice of local law requirement.For more information,please see here.Previous123456NextMechanical Properties of Axons - CORE

The mechanical model proposed by Dennerll et al.[ J.Cell Biol.109 3073 (1989)],which involves three mechanical devicesa stiff spring coupled with a Voigt element that includes a less stiff spring k and a dashpot has been improved by adding a new element to describe the main features of the contraction of axons.Some results are removed in response to a notice of local law requirement.For more information,please see here.Simulation of the Mechanical Behavior of White Matter The atypical mechanical behavior of white matter and its influence on the mechanical properties of brain tissue necessitate adoption of a mutli-scale model of white matter for accurate computational analysis.Herein,we present a micromechanical analysis coupled with finite elements into a biomechanical interacting model of white matter.

Role of lipid composition on the structural and mechanical

May 29,2019 Mechanical Properties of Axons#0183;Axons are long projections of the nerve cell that are characterized by an excitable plasma membrane.In myelinated axons,patches of axon membrane are wrapped into myelin sheath,which enables a Opposite rheological properties of neuronal mechanical and rigidity-sensing properties within neuron microcompartments in the preferential damage of axons during traumatic brain injury and into potential mechanisms of axonal outgrowth after injury.M icrocompartments are an essential design feature in mammalian cells.For instance,motile cells useOcular Tissues Biomechanics - Nguyen LabThe mechanical properties of the cornea and sclera arise from the anisotropic fibrous microstructure of the stroma,which contains densely stacked lamellae primarily of type I collagen fibrils embedded in a hydrated matrix of proteoglycans. Glaucoma is a blinding disease characterized by progressive degeneration of the axons of retinal

Modeling of the axon membrane skeleton structure and

Feb 27,2017 Mechanical Properties of Axons#0183;To understand the mechanical properties of the axon,we introduced a coarse-grain molecular dynamics model for the axon membrane skeleton of non-myelinated neurons.We found that the axon plasma membrane has two distinct Young's moduli that are correlated with its geometric structure,which is characterized by stiff actin rings connected by extended spectrin filaments orientedMechanical properties of tissues of the nervous system The work presented is a review of the scientific literature pertaining to the mechanical properties of the tissues of the nervous system.Additional articles are reviewed where appropriate to indicate the scope of the total literature pertinent to the subject.PreliminaryMechanical properties of common steel - TubeconMECHANICAL PROPERTIES Mechanical Properties of Steel.The physical properties of steel include high strength,low weight,durability,ductility and corrosive resistance.Steel offers great strength,even though it is light in weight.In fact,the ratio of strength to weight for steel is

Mechanical properties of axons.- Abstract - Europe PMC

Aug 01,2007 Mechanical Properties of Axons#0183;This element,which represents the action of molecular motors,acts in parallel with viscous forces defining a global tension response of axons T against elongation rates delta(k).Under certain conditions,axons show a transition from a viscoelastic elongation to active contraction,suggesting the presence of a negative elongation rate sensitivity in the curve T vs delta(k).Mechanical characterization of squid giant axon membrane Jun 20,2019 Mechanical Properties of Axons#0183;A need for mechanical properties of the axons,and especially of its membrane sheath,was also expressed by the axonal modelling community.Recently,in fact,the connection between mechanical and Mechanical Properties of Titanium Alloys - Dierk Raabe Mechanical Properties of AxonsMicrostructure design and mechanical properties in a near-alpha Ti4Mo alloy Acta Materialia 97 (2015) 291-304 Microstructure design and mechanical properties in a near-a Ti4Mo alloy Z.Tarzimoghadam,S.Sandl Mechanical Properties of Axons#246;bes,K.G.Pradeep,D.Raabe Acta Materialia 97 (2015) 291

Mechanical Properties of Titanium Alloys - Dierk Raabe Mechanical Properties of Axons

Microstructure design and mechanical properties in a near-alpha Ti4Mo alloy Acta Materialia 97 (2015) 291-304 Microstructure design and mechanical properties in a near-a Ti4Mo alloy Z.Tarzimoghadam,S.Sandl Mechanical Properties of Axons#246;bes,K.G.Pradeep,D.Raabe Acta Materialia 97 (2015) 291Mechanical Properties of Iron Density of IronMechanical properties of Iron comprise of its density,tensile strength,viscosity,vapor pressureMechanical Properties of Engineering Materials Electrical4UMar 23,2019 Mechanical Properties of Axons#0183;To finalize the material for an engineering product or application,is it important to understand the mechanical properties of the material.The mechanical properties of a material are those which affect the mechanical strength and ability of a material to be molded in suitable shape.Some of the typical mechanical properties of a material include:

Mechanical Properties of Bone Musculoskeletal Key

The mechanical properties of bones are governed by the same principles as those of manmade load-bearing structures.However,the ability of vertebrates to adapt their bone structure to the imposed loading,in terms of both the evolution of a genetic plan for the skeleton and the ability to acutely modify this plan by cellular activity,results in a structure that is highly complex and,when Mechanical Properties of Axonsproperties of axons are expected to be important physi-ologically in axonal retraction after injury or during rewir-ing [6],and in stretching during limb movement [7].Using PC12 neurites as a model system for axons [8,9],we perform a systematic investigation of their mechanical response.We employ an axon-pulling setup and a micro-Mechanical Properties of Axons - ResearchGateThe active as well as viscoelastic properties of axons are expected to be important phys- iologically in axonal retraction after injury or during rewiring,and in stretching during limb movement.

Mechanical Properties of Axons - CORE

The mechanical model proposed by Dennerll et al.[ J.Cell Biol.109 3073 (1989)],which involves three mechanical devicesa stiff spring coupled with a Voigt element that includes a less stiff spring k and a dashpot has been improved by adding a new element to describe the main features of the contraction of axons.Mechanical Properties of Axons - COREThe mechanical model proposed by Dennerll et al.[ J.Cell Biol.109 3073 (1989)],which involves three mechanical devicesa stiff spring coupled with a Voigt element that includes a less stiff spring k and a dashpot has been improved by adding a new element to describe the main features of the contraction of axons.Description of mechanical properties - ArcelorMittalDescription of mechanical properties 1 Introduction Mechanical properties are governed by the basic concepts of elasticity,plasticity and toughness.Elasticity is the capacity of a metal to undergo temporary deformation.As soon as the load that caused this deformation is removed,the

Contribution of cytoskeletal elements to the axonal

Sep 04,2013 Mechanical Properties of Axons#0183;Microtubules,microfilaments,and neurofilaments are cytoskeletal elements that affect cell morphology,cellular processes,and mechanical structures in neural cells.The objective of the current study was to investigate the contribution of each type of cytoskeletal element to the mechanical properties of axons of dorsal root and sympathetic ganglia cells in chick embryos.Contribution of Cytoskeletal Elements to the Mechanical Microtubules,microfilaments,and neurofilaments are cytoskeletal elements that affect cell morphology,cellular processes,and mechanical structures in neural cells.The objective of the current study was to investigate the contribution of each type of cytoskeletal element to the mechanical properties of axons of dorsal root and sympathetic ganglia cells in chick embryos.Cited by 33Publish Year 2017Author Yihao Zhang,Krithika Abiraman,He Li,David M.Pierce,Anastasios V.Tzingounis,George LykotrafitiMechanical surface waves accompany action potential Mechanical Properties of Axons#0183;Although the mechanical properties of the squid giant axons sheath and cytoskeleton are not known quantitatively enough for our purposes,we use =300J

Cited by 117Publish Year 2007Author Roberto Bernal,Pramod A.Pullarkat,Francisco MeloStructure and Biomechanics of Peripheral Nerves Nerve

AbstractNerve StructureBiomechanical Properties of NervesResponses of Nerves to Physical StressesSummaryThere has been an emergence in physical therapy of evaluation and intervention based on neurodynamics,the relationship between nerve physiology and nerve mechanics.1 To advance the clinical care of people with nerve injuries,it is essential to understand peripheral nerve structure and plasticity.The purpose of this appraisal is to review the structural and biomechanical properties of peripheral nerves and then to discuss how nerves respond to physical stresses.We will expand on theSee more on academic.oupModeling of the axon membrane skeleton structure and Feb 27,2017 Mechanical Properties of Axons#0183;Super-resolution microscopy recently revealed that,unlike the soma and dendrites,the axon membrane skeleton is structured as a series of actin rings connected by spectrin filaments that are held under tension.Currently,the structure-function relationship of the axonal structure is unclear.CiteSeerX RESEARCH Contribution of cytoskeletalThe objective of the current study was to investigate the contribution of each type of cytoskeletal element to the mechanical properties of axons of dorsal root and sympathetic ganglia cells in chick embryos.Results Microtubules,microfilaments,and neurofilaments in axons were disrupted by nocodazole,cytochalasin D,and acrylamide Cell BioPhys LabBoth in the peripheral nerves and in the brain (which is as soft as jelly),axons are highly susceptible to mechanical damage.We are interested in understanding how the structural organisation of the axonal cytoskeleton imparts unique mechanical properties which help axons withstand sudden deformations.

CNS Cell Distribution and Axon Orientation Determine

Article CNS Cell Distribution and Axon Orientation Determine Local Spinal Cord Mechanical Properties David E.Koser,1,2 Emad Moeendarbary,1 Janina Hanne,1 Stefanie Kuerten,2,3 and Kristian Franze1,* 1Department of Physiology,Development and Neuroscience,University of Cambridge,Cambridge,United Kingdom; 2Department of Anatomy I,University of Cologne,Cologne,Germany; andCNS Cell Distribution and Axon Orientation Determine Local May 05,2015 Mechanical Properties of Axons#0183;Furthermore,anisotropy in CNS tissue structure because of the different orientations of the axons is likely the origin of the anisotropy in mechanical properties we found in white matter (Figs.3 and 5).Spinal cord white matter is highly structured; it consists of parallel,densely packed,myelinated axons.Artificial axons as a myelination assay for drug screening Finding cures for neurological diseases is challenging.Most drug candidates fail in clinical trials,in part due to the lack of adequate in vitro drug screening platforms that credibly represent the neural tissue environment.We are developing Artificial Axons,a novel drug-screening platform that mimics biological and mechanical properties of neuronal axons.

AXON Engineering Inc.(Mechanical and Electrical Engineers)

Axon Engineering Inc.based in Toronto is a full service Mechanical Electrical Engineering firm that provides practical engineering solutions to its clients.A micromechanical procedure for modelling the anisotropic The results will clearly demonstrate the undulation and axon volume fraction impacts.In this respect,undulation affects the material stiffness heavily in the axon longitudinal direction,whereas the axons' volume fraction has a much greater impact on the mechanical properties of the white matter in general.A Model of the Spatially Dependent Mechanicalthe mechanical properties of the overall axon are ultimately calculated based on mi-crotubule occupancy.The calculations are done with our dedicated nite difference solver Neurite.The overall approach is described in detail in Section 2.The nite difference dis-

13 Mechanical Properties of Materials You Must Know

Jul 24,2020 Mechanical Properties of Axons#0183;The mechanical properties of materials define the behaviour of materials under the action of external forces called loads..There are a measure of strength and lasting characteristics of the material in service and are of good importance in the design of tools,machines,and structures..The mechanical properties of metals are determined by the range of usefulness of the metal and12345NextA Model of the Spatially Dependent Mechanicalmechanical properties has been mostly disregarded.We thus propose a new model aimed at providing the spatially dependent mechanical properties of the axon dur-ing its growth.Our in-house nite difference solver Neurite is used to describe the guanosine triphosphate (GTP) transport through the axon,its dephosphoryla-

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